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KMID : 0363219940320030438
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Korean Journal of Dermatology
1994 Volume.32 No. 3 p.438 ~ p.445
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Ommunohistochemical Study of TGF-alpha, EGF and EGF Receptor on the Epithelial Tumors of the Skin
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Abstract
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Background:
@EN Several reports have demonstrated that TGFαand EGF are mitogenic for keratinocytes. Whenther its expression on epithelial tumors is a marker of malignancy or signifies an important step in the development of neoplasia is poorly understood.
EGF
receptors are also present in normal epidermis and epithelial tumors but their physiological roles are not yet understood.
@ES Objective:
@EN Our purpose was to examine the staining patterns of TGFα, EGF and EGF receptors on the npithelial tumors of the skin, and to investigate kinetics of expression of EGF receptors.
@ES Methods:
@EN We performed immunoperoxidase staining(ABC technique) with monoclonal anti-TGFαantibody, polyclonal anti-EGF antibody and polyclonal anti-EGF receptor antibody on the formalinfixed, paraffin-embedded tissue specimens of benign, premalignant
and
malignant skin tumors.
@ES Results:
@EN The density of the expression of TGFαand EGF was not correlated with the degree of the malignancy of the epithelial tumors and is neither constant in any kind of the tumors.
However the infiltrative type of basal cell carcinoma(BCC) is stronger that its solid type on the expression of TGFαand EGF. All benign tumors demonstrated a diffuse pattern within tumor lobules. pression of TGFα and EGF. All benign tumors
demonstrated a diffuse pattern within tumor lobules. Focal TGFα immunostaining was seen in three of 10 squamous cell carcinomas(SCC) and four of 10 BCCs. TGFα immunostaining was absent from the outermost one to two layers of tumor lobules of
all
keratoacanthomas. The specimens which increased the expression of TGFα and EGF tended to decrease the expression of EGF receptor.
@ES Conclusion:
@EN These data suggest that the density of immunohistochemical expression of TGFα and EGF may be not dependent on the differentiation of tumor cells, and the pattern of immunohistochemical expression of TGFα can differentiate SCC from benign
tumors
such as keratoacanthoma. FGF receptor may be occupied by both of TGFα and EGF. With the receptors being occupied, a down regulation of the receptors may occur which results in decreased EGF receptor expression.(Kor J Dermatol 1994; 32(3):
438~445)
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